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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: INPP5D All Species: 11.52
Human Site: T963 Identified Species: 25.33
UniProt: Q92835 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92835 NP_001017915.1 1189 133292 T963 C R G E S P P T P P G Q P P I
Chimpanzee Pan troglodytes XP_526066 929 104074 A720 K K F L P S T A N R G L P A R
Rhesus Macaque Macaca mulatta XP_001114794 1258 138636 L997 E G V P H Q L L P P E P P S P
Dog Lupus familis XP_542327 1264 138869 L1003 E G V P H Q L L P P E P P S P
Cat Felis silvestris
Mouse Mus musculus Q9ES52 1191 133524 T964 G R G E G P P T P P S Q P P L
Rat Rattus norvegicus P97573 1190 133575 T963 G R G E G P P T P P S Q P P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520934 1019 113512 E810 S S G E G F L E S L D R T Q N
Chicken Gallus gallus XP_422567 1182 133482 S965 S P S L S P L S P K P S L Q T
Frog Xenopus laevis Q6P4S2 1019 115278 S810 K S S D T D E S Y G E G C I A
Zebra Danio Brachydanio rerio Q2I6J1 1266 140353 S1002 P A G S V G K S K P P S G S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789838 1327 148052 T1035 S A T P M S A T P M S A T P M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.8 41.3 40.9 N.A. 87.8 87.8 N.A. 38.7 68.2 56.5 43.1 N.A. N.A. N.A. N.A. 31
Protein Similarity: 100 77.8 57.5 56.8 N.A. 92.1 92 N.A. 48.5 78.7 67.1 57.9 N.A. N.A. N.A. N.A. 47.3
P-Site Identity: 100 13.3 20 20 N.A. 73.3 73.3 N.A. 13.3 20 0 13.3 N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 20 20 20 N.A. 80 80 N.A. 20 26.6 20 20 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 0 0 0 10 10 0 0 0 10 0 10 10 % A
% Cys: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 0 0 10 0 10 0 0 0 0 10 0 0 0 0 % D
% Glu: 19 0 0 37 0 0 10 10 0 0 28 0 0 0 0 % E
% Phe: 0 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 19 19 46 0 28 10 0 0 0 10 19 10 10 0 0 % G
% His: 0 0 0 0 19 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % I
% Lys: 19 10 0 0 0 0 10 0 10 10 0 0 0 0 0 % K
% Leu: 0 0 0 19 0 0 37 19 0 10 0 10 10 0 19 % L
% Met: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 10 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 10 % N
% Pro: 10 10 0 28 10 37 28 0 64 55 19 19 55 37 19 % P
% Gln: 0 0 0 0 0 19 0 0 0 0 0 28 0 19 0 % Q
% Arg: 0 28 0 0 0 0 0 0 0 10 0 10 0 0 10 % R
% Ser: 28 19 19 10 19 19 0 28 10 0 28 19 0 28 10 % S
% Thr: 0 0 10 0 10 0 10 37 0 0 0 0 19 0 10 % T
% Val: 0 0 19 0 10 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _